Relief Reports Successful Conclusion of Patent Examination Procedure for Patent Application Entitled, ‘Vasoactive Intestinal Peptide (VIP) for the Use in the Treatment of Drug-induced Pneumonitis’ – Yahoo Finance UK

RELIEF THERAPEUTICS Holding AG / Key word(s): Patent

28-Dec-2021 / 07:00 CET/CEST
Release of an ad hoc announcement pursuant to Art. 53 LR
The issuer is solely responsible for the content of this announcement.

Relief Therapeutics Reports the Successful Conclusion of the Patent Examination Procedure for the Patent Application Entitled, “Vasoactive Intestinal Peptide (VIP) for the Use in the Treatment of Drug-induced Pneumonitis”

Geneva, Switzerland, December 28, 2021 – RELIEF THERAPEUTICS Holding SA (SIX: RLF, OTCQB: RLFTF, RLFTY) (“Relief“), a biopharmaceutical company seeking to provide patients therapeutic relief from serious diseases with high unmet need, reported today that the Swiss Patent Office IPI has announced that it expects to conclude the patent application procedure by January 24, 2022 and to issue the patent entitled, “Vasoactive Intestinal Peptide (VIP) for the Use in the Treatment of Drug-induced Pneumonitis,” as applied for by Relief’s subsidiary, AdVita Lifescience GmbH, in 2020. The patent will be formally issued, at the earliest, one month after the conclusion of the patent examination procedure.

“The pending grant of this Swiss patent for the inhaled version of RLF-100(TM) (aviptadil) represents another important milestone for the Company and further solidifies our growing intellectual property portfolio,” stated Raghuram (Ram) Selvaraju, Chairman of Relief. “The potential benefits of this inhaled formulation of RLF-100(TM) are intriguing and a number of studies to assess its advantages remain ongoing, including a clinical program in Europe as well as the National Institutes of Health (“NIH”)-sponsored ACTIVE-3b/TESICO study and the I-SPY trial sponsored by Quantum Leap.”

Immune checkpoint inhibitor therapy has become a new therapeutic option for several types of cancer, but immune related negative adverse events can limit their use. Outside of clinical studies, pneumonitis develops in as many as 10% to 20% of patients who are treated with immune checkpoint inhibitors, a complication that leads to discontinuation of treatment and to immunosuppressive therapy. Moreover, these patients suffer from recurrent pneumonitis even after immune checkpoint inhibitor treatment discontinuation and receipt of glucocorticoid treatment, according to current guidelines. Respiratory symptoms are demonstrated on computed tomography showing widespread consolidations and are denoted on Quality of Life Questionnaires. Patients experience severe lymphocytosis with a decreased number of regulatory T cells. As a result, there is an urgent need for an effective, safe treatment of checkpoint inhibitor-induced pneumonitis.

The unexpected finding that the synthetic form of Vasoactive Intestinal Peptide (aviptadil) administered via inhalation was well tolerated and led to dampening of alveolar inflammation, radiological and clinical improvement of pneumonitis resulting from a checkpoint inhibitor therapy for melanoma, was the basis for this issued Patent.

Inhalation is the preferred route of aviptadil administration in that it, (1) acts quickly, minimizing potentially undesired negative side effects (2) avoids the hepatic first-pass …….

Source: https://uk.finance.yahoo.com/news/relief-reports-successful-conclusion-patent-060021314.html